A novel anti-HIV macrocyclic peptide from Palicourea condensata

J Nat Prod. 2001 Feb;64(2):249-50. doi: 10.1021/np000372l.

Abstract

A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Cyclotides*
  • Cytopathogenic Effect, Viral / drug effects
  • Disulfides / analysis
  • Humans
  • Molecular Sequence Data
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Protein Conformation
  • Rubiaceae / chemistry*
  • Trees / chemistry

Substances

  • Anti-HIV Agents
  • Cyclotides
  • Disulfides
  • Peptides, Cyclic
  • palicourein