Abstract
A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Cells, Cultured
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Chromatography, High Pressure Liquid
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Cyclotides*
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Cytopathogenic Effect, Viral / drug effects
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Disulfides / analysis
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Humans
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Molecular Sequence Data
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Protein Conformation
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Rubiaceae / chemistry*
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Trees / chemistry
Substances
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Anti-HIV Agents
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Cyclotides
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Disulfides
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Peptides, Cyclic
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palicourein