Anandamide: some like it hot

Trends Pharmacol Sci. 2001 Jul;22(7):346-9. doi: 10.1016/s0165-6147(00)01712-0.

Abstract

Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial. However, very recent reports demonstrate that activation of VR1 by anandamide can be significantly enhanced by various regulatory factors, suggesting that this compound might act as an "endovanilloid" under certain conditions.

Publication types

  • Review

MeSH terms

  • Animals
  • Arachidonic Acids / chemistry
  • Arachidonic Acids / metabolism
  • Arachidonic Acids / pharmacology*
  • Brain / drug effects
  • Brain / metabolism
  • Calcium Channel Blockers / chemistry
  • Calcium Channel Blockers / metabolism
  • Calcium Channel Blockers / pharmacology*
  • Capsaicin / pharmacology
  • Endocannabinoids
  • Humans
  • Neurons, Afferent / drug effects
  • Neurons, Afferent / metabolism
  • Polyunsaturated Alkamides
  • Receptors, Drug / drug effects*
  • Receptors, Drug / metabolism

Substances

  • Arachidonic Acids
  • Calcium Channel Blockers
  • Endocannabinoids
  • Polyunsaturated Alkamides
  • Receptors, Drug
  • Capsaicin
  • anandamide