Gastric emptying is accelerated in obese type 2 diabetic patients without autonomic neuropathy

Diabetes Metab. 2001 Jun;27(3):357-64.

Abstract

Objective: To clarify the impact of type 2 diabetes mellitus on the gastric emptying rate.

Material and methods: Using a double-isotope scintigraphic technique, we assessed the gastric emptying of a standard liquid-solid meal in 13 obese type 2 diabetic patients without autonomic neuropathy (age: 47.4 +/- 8.6 yr, body mass index: 33.9 +/- 4.8 kg/m(2), glycaemia: 9.1 +/- 2.6 mmol/l) and in 7 controls with similar sex ratio, age, BMI and body fat distribution.

Results: The half gastric emptying time for the liquid phase was not significantly different between diabetic patients and controls (respectively: 52.7 +/- 14.5 min and 63.1 +/- 15.2 min). However, the half gastric emptying time for the solid phase was significantly shortened in diabetic patients versus controls (respectively 88.8 +/- 23.2 min in diabetic patients and 113.6 +/- 26.9 min in controls; p<0.04). Furthermore, a negative relationship was highlighted between the half gastric emptying time for the solid phase and basal glycaemia (r=-0.65, p<0.02) in diabetic patients. No significant relationship was found between gastric emptying parameters and cardiac autonomic nerve function, insulin or gastrin levels.

Conclusion: Solid gastric emptying is accelerated in obese type 2 diabetic patients without patent autonomic neuropathy when compared to obese non diabetic patients.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Blood Glucose / metabolism
  • Body Mass Index
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / physiopathology*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetic Neuropathies
  • Female
  • Gastric Emptying / physiology*
  • Glycated Hemoglobin A / analysis
  • Humans
  • Indium Radioisotopes
  • Male
  • Middle Aged
  • Obesity*
  • Patient Selection
  • Pentetic Acid
  • Radiopharmaceuticals
  • Reference Values
  • Technetium Tc 99m Aggregated Albumin

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Indium Radioisotopes
  • Radiopharmaceuticals
  • Technetium Tc 99m Aggregated Albumin
  • technetium Tc 99m nanocolloid
  • Pentetic Acid