Sox9 induces testis development in XX transgenic mice

V P Vidal; M C Chaboissier; D G de Rooij; A Schedl

doi:10.1038/90046

Sox9 induces testis development in XX transgenic mice

Nat Genet. 2001 Jul;28(3):216-7. doi: 10.1038/90046.

Authors

V P Vidal¹, M C Chaboissier, D G de Rooij, A Schedl

Affiliation

¹ MDC for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin, Germany.

PMID: 11431689
DOI: 10.1038/90046

Abstract

Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disorders of Sex Development*
Female
High Mobility Group Proteins / genetics*
Male
Mice
Mice, Transgenic
Phenotype
SOX9 Transcription Factor
Transcription Factors / genetics*
X Chromosome / genetics*

Substances

High Mobility Group Proteins
SOX9 Transcription Factor
SOX9 protein, human
Sox9 protein, mouse
Transcription Factors