Sox9 induces testis development in XX transgenic mice

Nat Genet. 2001 Jul;28(3):216-7. doi: 10.1038/90046.


Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disorders of Sex Development*
  • Female
  • High Mobility Group Proteins / genetics*
  • Male
  • Mice
  • Mice, Transgenic
  • Phenotype
  • SOX9 Transcription Factor
  • Transcription Factors / genetics*
  • X Chromosome / genetics*


  • High Mobility Group Proteins
  • SOX9 Transcription Factor
  • SOX9 protein, human
  • Sox9 protein, mouse
  • Transcription Factors