Oral polymeric N-acetyl-D-glucosamine and osteoarthritis

J Am Osteopath Assoc. 2001 Jun;101(6):339-44.


Many patients with arthritis are using alternative modes of therapy, including nutritional supplements, to treat their arthritis. Most patients never tell their doctors that they are taking alternative medications, and few doctors even ask about such activities. Over-the-counter supplements are expensive and consume large amounts of patients' healthcare dollars. Glucosamine has been widely touted as being an effective arthritis treatment. The authors designed and undertook a study to test the efficacy of a polymer of N-acetyl-D-glucosamine (NAG), or POLY-Nag, in a double-blind, placebo-controlled study in patients with osteoarthritis. Results indicate that POLY-Nag may be useful in treating patients with osteoarthritis.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylglucosamine / administration & dosage
  • Administration, Oral
  • Adult
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Glucosamine / administration & dosage*
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis / diagnosis
  • Osteoarthritis / drug therapy*
  • Pain Measurement
  • Pilot Projects
  • Range of Motion, Articular / drug effects
  • Sensitivity and Specificity
  • Treatment Outcome


  • Glucosamine
  • Acetylglucosamine