Treatment of Complicated Sarcoidosis With Infliximab Anti-Tumor Necrosis Factor-Alpha Therapy

Ann Intern Med. 2001 Jul 3;135(1):27-31. doi: 10.7326/0003-4819-135-1-200107030-00010.

Abstract

Background: Tumor necrosis factor-alpha (TNF-alpha) may have an important role in the clinical exacerbation of sarcoidosis.

Objective: To treat sarcoidosis with infliximab, a chimeric human-murine anti-human TNF-alpha monoclonal antibody.

Design: Case report.

Setting: U.S. academic medical center.

Patient: A 72-year-old woman with sarcoidosis presenting with severe protein-losing enteropathy, hypoalbuminemia, and proximal myopathy who had not responded adequately to corticosteroid therapy and whose clinical course was further complicated by acute tubular necrosis and renal failure requiring long-term hemodialysis.

Intervention: Intravenous infusion of infliximab, 5 mg/kg of ideal body weight; infusion was repeated at 2 and 6 weeks.

Measurements: Clinical response of enteropathic and myopathic symptoms and serum albumin level.

Results: Enteropathic and myopathic symptoms resolved after infliximab therapy, and the serum albumin level also improved. However, the clinical course was complicated by the development of a hypercoagulable state associated with circulating anticardiolipin antibodies, which prompted discontinuation of infliximab therapy.

Conclusions: Infliximab therapy was successful in a patient with sarcoidosis. Tumor necrosis factor-alpha may be an important mediator of clinical disease in sarcoidosis and could be an attractive target for therapeutic intervention. However, infliximab may cause adverse effects associated with cytokine cascade manipulation.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / therapy
  • Aged
  • Antibodies, Monoclonal / adverse effects
  • Antibodies, Monoclonal / therapeutic use*
  • Drug Administration Schedule
  • Female
  • Humans
  • Infliximab
  • Kidney Tubular Necrosis, Acute / complications
  • Lung Diseases / blood
  • Lung Diseases / complications
  • Lung Diseases / drug therapy*
  • Muscle Weakness / complications
  • Muscle Weakness / drug therapy
  • Protein-Losing Enteropathies / complications
  • Protein-Losing Enteropathies / drug therapy
  • Renal Dialysis
  • Sarcoidosis / blood
  • Sarcoidosis / complications
  • Sarcoidosis / drug therapy*
  • Serum Albumin / metabolism
  • Thrombosis / chemically induced
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Antibodies, Monoclonal
  • Serum Albumin
  • Tumor Necrosis Factor-alpha
  • Infliximab