Investigation of serum response to PMP22, connexin 32 and P(0) in inflammatory neuropathies

J Neuroimmunol. 2001 Jun 1;116(2):220-5. doi: 10.1016/s0165-5728(01)00307-1.

Abstract

We investigated serological immune responses against three major peripheral nerve myelin constituents in patients with immune-mediated neuropathies. Connexin 32 (Cx32), myelin protein zero (MPZ, P(0)) and peripheral myelin protein 22 (PMP22) were produced in Chinese hamster ovary (CHO)-K1 cells. From a panel of 25 Guillain-Barré syndrome (GBS) and 24 chronic inflammatory demyelinating polyneuropathy (CIDP) patients, only two patients showed reactivity towards Cx32 and P(0).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantibodies / blood*
  • CHO Cells
  • Connexins / genetics
  • Connexins / immunology*
  • Cricetinae
  • Gene Expression
  • Guillain-Barre Syndrome / immunology*
  • Humans
  • Microscopy, Fluorescence
  • Myelin P0 Protein / genetics
  • Myelin P0 Protein / immunology*
  • Myelin Proteins / genetics
  • Myelin Proteins / immunology*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology
  • Recombinant Proteins / immunology
  • Transfection

Substances

  • Autoantibodies
  • Connexins
  • Myelin P0 Protein
  • Myelin Proteins
  • PMP22 protein, human
  • Recombinant Proteins
  • connexin 32