Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice

Arch Pharm Res. 2001 Jun;24(3):214-8. doi: 10.1007/BF02978260.


The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-gamma expression in adipose tissue were examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-y protein expression as well as inhibiting intestinal glucose absorption.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Blotting, Western
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / genetics*
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / blood
  • Intestinal Absorption
  • Liver / enzymology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Panax*
  • Phytotherapy*
  • Plant Extracts / therapeutic use
  • Plant Roots / chemistry
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Transcription Factors / metabolism


  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Plant Extracts
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors