Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma

Acta Biochim Pol. 2001;48(1):277-82.


We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dimerization*
  • Melanoma / therapy*
  • Models, Chemical
  • Oxygen / metabolism
  • Photochemotherapy*
  • Photosensitizing Agents / pharmacology*
  • Porphyrins / chemical synthesis*
  • Porphyrins / chemistry*
  • Porphyrins / pharmacology*
  • Spectrophotometry
  • Temperature
  • Time Factors
  • Ultraviolet Rays


  • 10,15,20-tritolylporphyrin-5-(4-amidophenyl)-(5-(4-phenyl)-10,15,20-tritolylporphyrin)
  • Photosensitizing Agents
  • Porphyrins
  • Oxygen