Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain

Trends Biochem Sci. 2001 Jul;26(7):407-9. doi: 10.1016/s0968-0004(01)01861-8.


This article describes the discovery of a novel SNARE domain that might be involved in the regulation of membrane fusion. This domain is shared by a novel family of VAMPs called long VAMPs or longins. Members of this family are more conserved among eukaryotes than are classical VAMPs, possibly because of their underlying basic SNARE function.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Evolution, Molecular
  • Humans
  • Membrane Proteins / chemistry*
  • Molecular Sequence Data
  • Multigene Family
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • SNARE Proteins
  • Sequence Homology, Amino Acid
  • Vesicular Transport Proteins*


  • Membrane Proteins
  • SNARE Proteins
  • Vesicular Transport Proteins