Combinatorial control of protein phosphatase-1

Trends Biochem Sci. 2001 Jul;26(7):426-31. doi: 10.1016/s0968-0004(01)01836-9.


The catalytic subunit of the type 1 Ser/Thr protein phosphatases (PP1) can interact with many different regulatory (R) subunits. These R subunits function as activity-modulators, targeting subunits and/or substrates. The specificity of the R subunits can be accounted for by their interaction with specific subsets of binding pockets on the catalytic subunit and by the presence of subcellular targeting sequences. Hormones, growth factors and metabolites control the function of PP1 holoenzymes mainly by modulating the interaction of the subunits.

MeSH terms

  • Allosteric Site
  • Animals
  • Binding Sites
  • Catalytic Domain
  • Models, Molecular
  • Phosphoprotein Phosphatases / chemistry*
  • Protein Binding
  • Protein Conformation
  • Protein Isoforms
  • Protein Phosphatase 1
  • Protein Structure, Tertiary


  • Protein Isoforms
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 1