Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate

Microb Drug Resist. 2001 Summer;7(2):99-125. doi: 10.1089/10766290152044995.


The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.

MeSH terms

  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Genes, Bacterial / genetics
  • Genome, Bacterial*
  • Molecular Sequence Data
  • Pneumococcal Infections / microbiology*
  • Prokaryotic Cells
  • RNA, Transfer / metabolism
  • Streptococcus pneumoniae / genetics*


  • DNA, Bacterial
  • RNA, Transfer

Associated data

  • GENBANK/AL449923
  • GENBANK/AL449924
  • GENBANK/AL449925
  • GENBANK/AL449926
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  • GENBANK/AL449947
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  • GENBANK/AL449949
  • GENBANK/AL449950
  • GENBANK/AL449951
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  • GENBANK/AL449953