True Histiocytic Lymphoma Following B-acute Lymphoblastic Leukaemia: Case Report With Evidence for a Common Clonal Origin in Both Neoplasms

Br J Haematol. 2001 Jun;113(4):1047-50. doi: 10.1046/j.1365-2141.2001.02841.x.


True histiocytic lymphoma (THL) is a very rare type of non-Hodgkin's lymphoma (NHL) in which neoplastic cells exhibit markers of histiocytic differentiation. Some cases of THL have been reported in patients with previous acute lymphoblastic leukaemia (ALL), especially in children and young adults, in whom the acute leukaemia was of T-cell origin. The relationship between the initial lymphoid tumour and the secondary THL remains unclear, as a common monoclonal origin shared by both neoplasms has never been definitively demonstrated. We report a patient with B-ALL who developed a nodal and extranodal tumour with histological and immunohistochemical features of THL 4 years after the initial diagnosis. Genotypic study showed that both neoplasms contained the same immunoglobulin heavy gene rearrangement, which has not been reported previously.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD / analysis
  • Antigens, Differentiation, Myelomonocytic / analysis
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Burkitt Lymphoma / complications*
  • Burkitt Lymphoma / diagnosis
  • Burkitt Lymphoma / genetics*
  • Cyclophosphamide / administration & dosage
  • Dacarbazine / administration & dosage
  • Daunorubicin / administration & dosage
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain*
  • Humans
  • Immunohistochemistry
  • Leukocyte Common Antigens / analysis
  • Lymphoma, Large B-Cell, Diffuse / complications*
  • Lymphoma, Large B-Cell, Diffuse / diagnosis
  • Lymphoma, Large B-Cell, Diffuse / genetics*
  • Male
  • Polymerase Chain Reaction
  • S100 Proteins / analysis


  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD68 antigen, human
  • S100 Proteins
  • Dacarbazine
  • Cyclophosphamide
  • Leukocyte Common Antigens
  • Daunorubicin