Molecular physiology of renal p-aminohippurate secretion

News Physiol Sci. 2001 Jun;16:114-8. doi: 10.1152/physiologyonline.2001.16.3.114.


Renal proximal tubules secrete various organic anions, including drugs and p-aminohippurate (PAH). Uptake of PAH from blood into tubule cells occurs by exchange with intracellular alpha-ketoglutarate and is mediated by the organic anion transporter 1. PAH exit into tubule lumen is species specific and may involve ATP-independent and -dependent transporters.

Publication types

  • Review

MeSH terms

  • Animals
  • Anion Transport Proteins
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism
  • Humans
  • Ketoglutaric Acids / metabolism
  • Kidney / metabolism*
  • Kidney Tubules, Proximal / cytology
  • Kidney Tubules, Proximal / metabolism
  • p-Aminohippuric Acid / metabolism*


  • Anion Transport Proteins
  • Carrier Proteins
  • Ketoglutaric Acids
  • p-Aminohippuric Acid