Molecular structure of tight junctions and their role in epithelial transport

News Physiol Sci. 2001 Jun;16:126-30. doi: 10.1152/physiologyonline.2001.16.3.126.


Tight junctions create a paracellular barrier with physiological properties that differ among epithelia. Among these differences are electrical resistance and discrimination for solute size and charge. Emerging evidence suggests that a large family of transmembrane proteins called the claudins create these variable properties.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Epithelial Cells / metabolism*
  • Membrane Proteins / physiology*
  • Occludin
  • Tight Junctions / metabolism*


  • Membrane Proteins
  • Occludin