Relationship of obesity distribution and peripheral arterial occlusive disease in elderly men

Int J Obes Relat Metab Disord. 2001 Jul;25(7):1068-70. doi: 10.1038/sj.ijo.0801638.


Objective: To examine the relationships between total body fatness and abdominal fat distribution with peripheral arterial disease.

Design: Cross-sectional.

Subjects: Population-based sample of 708 men aged 55-74.

Measurements: Body mass index (BMI) to estimate total body fatness and waist-to-hip ratio for abdominal fat distribution; peripheral arterial disease defined by ankle/brachial index <0.9; cardiovascular risk factors.

Results: Peripheral arterial disease was observed in 13.4% of subjects. BMI did not correlate with peripheral arterial disease, whereas an increased waist-to-hip ratio over 0.966 (median value) doubled the prevalence of arterial disease. After controlling for smoking, diabetes, hypertension, high-density lipoprotein cholesterol and triglycerides, increased waist-to-hip ratio was independently associated with peripheral arterial disease (odds ratio 1.68; 95% confidence interval 1.05-2.70).

Conclusion: Abdominal fat distribution, but not total body fatness, is associated with peripheral arterial occlusive disease, independently of concurrent cardiovascular risk factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / anatomy & histology*
  • Aged
  • Arterial Occlusive Diseases / etiology*
  • Body Constitution*
  • Body Mass Index
  • Cross-Sectional Studies
  • Humans
  • Male
  • Middle Aged
  • Obesity / complications*
  • Odds Ratio
  • Peripheral Vascular Diseases / etiology*
  • Risk Factors