Effects of anti-inflammatory agents on serum levels of calcitonin precursors during human experimental endotoxemia

J Infect Dis. 2001 Aug 1;184(3):373-6. doi: 10.1086/322031. Epub 2001 Jun 26.

Abstract

Calcitonin precursor (CTpr) levels are both markers and mediators of inflammation. The duration of their elevation after intravenous endotoxin challenge and the effects of anti-inflammatory therapies were studied in 52 subjects. CTpr levels maximized at 24 h in all subjects. At 7 days (n=4), after levels of acute-phase cytokines and C-reactive protein had normalized, CTpr levels remained 2-4-fold above baseline levels. The elimination half-life of CTpr levels ranged from 26.9 to 45.7 h. At 24 h, endotoxin and ibuprofen (compared with endotoxin alone) increased CTpr levels approximately 2-fold (P=.03), whereas soluble tumor necrosis factor receptor blunted the increase in CTpr levels by 2-3-fold (P=.0015). However, soluble interleukin-1 receptor failed to alter the increase in CTpr levels. Thus, the fact that anti-inflammatory agents may alter CTpr levels resulting from a single stimulus must be considered when CTpr is used as a clinical marker. Of importance, this study reveals that anti-inflammatory agents may modulate the CTpr level, which is a potential toxic mediator of inflammation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Biomarkers / blood
  • C-Reactive Protein / metabolism*
  • Calcitonin / blood*
  • Endotoxemia / blood*
  • Endotoxemia / physiopathology
  • Endotoxins / administration & dosage
  • Endotoxins / toxicity
  • Escherichia coli
  • Etanercept
  • Female
  • Half-Life
  • Humans
  • Ibuprofen / pharmacology*
  • Immunoglobulin G / pharmacology
  • Inflammation
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Placebos
  • Protein Precursors / blood*
  • Radioimmunoassay
  • Receptors, Tumor Necrosis Factor

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Biomarkers
  • Endotoxins
  • Immunoglobulin G
  • Placebos
  • Protein Precursors
  • Receptors, Tumor Necrosis Factor
  • Calcitonin
  • C-Reactive Protein
  • Etanercept
  • Ibuprofen