Alternative 1-(13)C glucose infusion protocols for clinical (13)C MRS examinations of the brain

Magn Reson Med. 2001 Jul;46(1):39-48. doi: 10.1002/mrm.1158.


Clinical utility of (13)C MRS is limited by cost and long examination times. Three 1-(13)C glucose infusion protocols-a high-dose i.v., low-dose i.v., and oral administration of 1-(13)C glucose-were compared on a GE 1.5T MR scanner. Resolution and sensitivity were sufficient to identify (13)C glucose (1alpha and 1beta), glutamate (C1-C4), glutamine (C1-C4), aspartate (C2 and C3), lactate, alanine, and bicarbonate in brain spectra. The three protocols were efficacious, as measured by cerebral enrichment of 1-(13)C glucose (62%, 42%, and 38%) and its principal metabolite, 4-(13)C glutamate (13%, 11%, and 16%), respectively. Intravenous infusion of 1-(13)C glucose 0.23 g/kg body weight (low dose) provides equivalent information at one third the cost of previous regimes. Magn Reson Med 46:39-48, 2001.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Brain / anatomy & histology
  • Brain / metabolism*
  • Carbon Isotopes
  • Child
  • Child, Preschool
  • Costs and Cost Analysis
  • Female
  • Glucose* / administration & dosage
  • Glucose* / metabolism
  • Glutamic Acid / metabolism
  • Humans
  • Infusions, Intravenous
  • Magnetic Resonance Spectroscopy* / methods
  • Male


  • Carbon Isotopes
  • Glutamic Acid
  • Glucose