[Immunomodulatory properties of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and search for its new derivatives]

V D Potapov; S F Biketov; G R Demina; E I Lysak; G M Titareva; I V Bakhteeva; D N Ostrovskiĭ

[Immunomodulatory properties of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and search for its new derivatives]

Prikl Biokhim Mikrobiol. 2001 May-Jun;37(3):274-8.

[Article in Russian]

Authors

V D Potapov¹, S F Biketov, G R Demina, E I Lysak, G M Titareva, I V Bakhteeva, D N Ostrovskiĭ

Affiliation

¹ State Research Center of Applied Microbiology, Obolensk, Moscow oblast, Russia.

PMID: 11443893

Abstract

A strong immunomodulatory effect of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) responsible for the survival of bacteria was shown on isolated macrophages and in experimental infections in mice (typhoid and tularemia). Derivatives of MEC were found by 1H-NMR spectroscopy under stress conditions in colorless mutants of the bacteria and isolated to be subsequently purified and used for modulation of the immune system of animals.

Publication types

English Abstract

MeSH terms

Adjuvants, Immunologic / chemistry
Adjuvants, Immunologic / pharmacology*
Animals
Corynebacterium
Erythritol / analogs & derivatives
Erythritol / chemistry
Erythritol / pharmacology*
Macrophages, Peritoneal / drug effects*
Macrophages, Peritoneal / immunology
Mice
Mice, Inbred BALB C
Phagocytosis / drug effects
Tularemia / immunology
Typhoid Fever / immunology

Substances

Adjuvants, Immunologic
2-methyl-butan-1,2,3,4-tetraol-2,4-cyclopyrophosphate
Erythritol