Clinical importance of extended-spectrum beta-lactamase (PER-1-type)-producing Acinetobacter spp. and Pseudomonas aeruginosa strains

J Med Microbiol. 2001 Jul;50(7):642-645. doi: 10.1099/0022-1317-50-7-642.


Recently, an extended-spectrum beta-lactamase (PER-1) was found to be disseminated among Acinetobacter spp. and Pseudomonasaeruginosa isolates in Turkey. A population-based cohort study was conducted to elucidate predictive mortality factors in patients with nosocomial infections caused by Acinetobacter spp. and P. aeruginosa, with particular reference to PER-1-type extended-spectrum beta-lactamase (ESBL) production. The study group comprised 16 and 21 non-survivors and 82 and 126 survivors in cohorts infected with Acinetobacter and P. aeruginosa, respectively. In the Acinetobacter-infected cohort, nosocomial pneumonia, hypotension and infection with a PER-positive isolate were independent predictors of mortality. In the P. aeruginosa-infected cohort, impaired consciousness, a PER-positive isolate, male sex and (with a negative relative risk) urinary tract infection were independent predictors of death. This study demonstrated the relationship of PER-1-type ESBL-producing Acinetobacter spp. and P. aeruginosa with poor clinical outcome.

MeSH terms

  • Acinetobacter / enzymology*
  • Acinetobacter Infections / genetics
  • Acinetobacter Infections / microbiology
  • Acinetobacter Infections / mortality*
  • Adult
  • Cohort Studies
  • Cross Infection / microbiology
  • Cross Infection / mortality*
  • Female
  • Humans
  • Male
  • Multivariate Analysis
  • Outcome Assessment, Health Care
  • Pneumonia, Bacterial / microbiology
  • Pneumonia, Bacterial / mortality
  • Prospective Studies
  • Pseudomonas Infections / genetics
  • Pseudomonas Infections / microbiology
  • Pseudomonas Infections / mortality*
  • Pseudomonas aeruginosa / enzymology*
  • Risk Factors
  • Sex Factors
  • Turkey / epidemiology
  • Urinary Tract Infections / microbiology
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics*


  • beta-lactamase PER-1
  • beta-Lactamases