Immunity to Bordetella pertussis

Microbes Infect. 2001 Jul;3(8):655-77. doi: 10.1016/s1286-4579(01)01421-6.

Abstract

Bordetella pertussis exploits extracellular and intracellular niches in the respiratory tract and a variety of immune evasion strategies to prolong its survival in the host. This article reviews evidence of complementary roles for cellular and humoral immunity in protection. It discusses the effector mechanisms of bacterial elimination, the strategies employed by the bacteria to subvert protective immune responses and the immunological basis for systemic and neurological responses to infection and vaccination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Bacterial / blood*
  • Bordetella pertussis / immunology*
  • Humans
  • Immunity, Cellular
  • Mice
  • Pertussis Vaccine / administration & dosage
  • Pertussis Vaccine / adverse effects
  • Pertussis Vaccine / immunology*
  • Whooping Cough / immunology*
  • Whooping Cough / prevention & control

Substances

  • Antibodies, Bacterial
  • Pertussis Vaccine