A prospective study of quality of life in ALS patients treated with noninvasive ventilation

Neurology. 2001 Jul 10;57(1):153-6. doi: 10.1212/wnl.57.1.153.


Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" domain by as much as 25%, for periods of up to 15 months, despite disease progression. Noninvasive positive pressure ventilation did not cause reduced quality of life, as any fall in scores in the ventilated group were comparable to those seen in a control group. In conclusion, noninvasive positive pressure ventilation enhances quality of life when used to treat sleep-disordered breathing in patients with ALS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amyotrophic Lateral Sclerosis / complications
  • Amyotrophic Lateral Sclerosis / physiopathology*
  • Amyotrophic Lateral Sclerosis / therapy*
  • Cohort Studies
  • Diaphragm / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Positive-Pressure Respiration*
  • Prospective Studies
  • Quality of Life*
  • Reference Values
  • Respiration Disorders / etiology
  • Respiration Disorders / physiopathology
  • Sleep Wake Disorders / etiology
  • Sleep Wake Disorders / physiopathology
  • Surveys and Questionnaires