The genetic factor in acute myocardial infarction with hypertension

Jpn Circ J. 2001 Jul;65(7):621-6. doi: 10.1253/jcj.65.621.


This study assessed the contribution of polymorphisms of angiotensin II (AngII) receptors and bradykinin B2 (BK-B2) receptor to hypertension and acute myocardial infarction (AMI) in a Japanese population: 150 subjects with essential hypertension, 150 subjects with AMI with/without hypertension, and 150 healthy, age- and sex-matched controls. Polymorphisms of the AngII type 1 receptor (1166 A/C) and type 2 receptor (3123 C/A), and the BK-B2 receptor (-58T/C, exon 1) were analyzed and significant differences of genotypes and allelic frequencies in the AngII type 2 receptor C/A and BK-B2 receptor -58T/C were found between the essential hypertension and control subjects. Further, a significantly higher incidence of the C allele of the BK-B2 receptor was seen in AMI subjects with hypertension compared with those without hypertension. Genetic variations in the AngII and BK-B2 receptors could prove to be significant pathophysiological mechanisms affecting essential hypertension and AMI, and genetic differences appear to be a new risk factor for these conditions.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Hypertension / complications
  • Hypertension / genetics*
  • Male
  • Middle Aged
  • Myocardial Infarction / complications
  • Myocardial Infarction / genetics*
  • Polymorphism, Genetic
  • Polymorphism, Single-Stranded Conformational
  • Receptor, Bradykinin B2
  • Receptors, Angiotensin / genetics
  • Receptors, Bradykinin / genetics
  • Retrospective Studies


  • Receptor, Bradykinin B2
  • Receptors, Angiotensin
  • Receptors, Bradykinin