Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey

J Hypertens. 2001 Jul;19(7):1209-15. doi: 10.1097/00004872-200107000-00005.

Abstract

Objective: To investigate the association of serum uric acid level with the risk for hypertension and Type 2 diabetes.

Design: Prospective cohort study.

Setting: Work site in Osaka, Japan.

Participants: A total of 6,356 Japanese men, aged 35-60 years with systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg, normal glucose intolerance, and no history of hypertension or diabetes at baseline.

Main outcome measures: Blood pressure was measured by standard techniques, using 160/95 mmHg for diagnosis of hypertension. Type 2 diabetes was defined as a fasting plasma glucose level > or = 126 mg/dl or a 2 h post-loaded plasma glucose level > or = 200 mg/dl.

Results: During the 61,716 person-years follow-up period, we confirmed 639 cases of hypertension and 454 cases of Type 2 diabetes. Serum uric acid level was associated with an increased risk for hypertension but not for Type 2 diabetes. After adjustment for known risk factors, including daily alcohol consumption, the serum uric acid level was associated with an increased risk for hypertension; the relative risks for hypertension were 1.00 for quintile 1 of the serum uric acid level, 1.24 [95% confidence interval (CI), 0.94-1.65] for quintile 2, 1.34 (CI, 1.03-1.76) for quintile 3, 1.76 (CI, 1.35-2.29) for quintile 4, and 2.01 (CI, 1.56-2.60) for quintile 5 (P for trend < 0.001). Even among both non-drinkers and lean subjects, serum uric acid level was associated with an increased risk for hypertension.

Conclusions: Serum uric acid level was associated with an increased risk for hypertension but not for Type 2 diabetes.

MeSH terms

  • Adult
  • Alcohol Drinking
  • Asian Continental Ancestry Group*
  • Body Mass Index
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / etiology*
  • Health Surveys*
  • Humans
  • Hypertension / etiology*
  • Japan
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Uric Acid / blood*

Substances

  • Uric Acid