Infectious complications in asplenic hosts

Infect Dis Clin North Am. 2001 Jun;15(2):551-65, x. doi: 10.1016/s0891-5520(05)70159-8.


Hyposplenism, secondary to splenectomy or disease state, predisposes the host to overwhelming infection with certain bacteria, such as S. pneumoniae. Recognition of the hyposplenic state and preventive measures, including patient education and vaccination, appear to reduce the rate of this highly fatal infection. In addition to considering chemoprophylaxis, a clinician should promptly evaluate or empirically treat all febrile episodes in hyposplenic patients.

Publication types

  • Review

MeSH terms

  • Humans
  • Postoperative Complications / microbiology*
  • Postoperative Complications / prevention & control
  • Practice Guidelines as Topic
  • Sepsis / microbiology
  • Sepsis / prevention & control
  • Splenectomy / adverse effects
  • Splenic Diseases / complications*
  • Vaccination