Axis formation and patterning in zebrafish

Curr Opin Genet Dev. 2001 Aug;11(4):393-404. doi: 10.1016/s0959-437x(00)00209-4.


A large collection of mutations affecting zebrafish embryogenesis was described in 1996. The cloning of the affected genes has now provided novel insights into the role and regulation of signaling by BMP, Nodal, Wnt, FGF, Hedgehog, Delta, Slit, retinoic acid and lipids. Detailed analyses have revealed a complex genetic network that patterns the early embryo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Axis, Cervical Vertebra / embryology*
  • Body Patterning / physiology*
  • Endoderm / physiology
  • Mesoderm / physiology
  • Zebrafish / embryology*