Profound effect of plasma protein binding on the polarized transport of furosemide and verapamil in the Caco-2 model

Pharm Res. 2001 Apr;18(4):544-7. doi: 10.1023/a:1011022931368.

Authors

S M Chung¹, E J Park, S M Swanson, T C Wu, W L Chiou

Affiliation

¹ Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy, University of Illinois at Chicago, USA.

PMID: 11451044
DOI: 10.1023/a:1011022931368

No abstract available

MeSH terms

Biological Transport / physiology
Caco-2 Cells / metabolism*
Calcium Channel Blockers / pharmacokinetics*
Diuretics / pharmacokinetics*
Furosemide / pharmacokinetics*
Humans
Protein Binding / physiology
Verapamil / pharmacokinetics*

Substances

Calcium Channel Blockers
Diuretics
Furosemide
Verapamil