Abstract
A multidrug-resistant plasmid encoding TEM-1, SHV-12, and a variant of IMP-2 metallo-beta-lactamase, designated IMP-8, was identified from a clinical isolate of Klebsiella pneumoniae. There are four nucleotide differences between bla(IMP-2) and bla(IMP-8), resulting in two amino acid differences. bla(IMP-8) was also found to be carried by an integron-borne gene cassette similar to the bla(IMP-2) cassette.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Bacterial Proteins*
-
Base Sequence
-
Cloning, Molecular
-
Drug Resistance, Microbial / genetics
-
Drug Resistance, Multiple
-
Humans
-
Isoelectric Focusing
-
Klebsiella pneumoniae / enzymology*
-
Klebsiella pneumoniae / isolation & purification
-
Microbial Sensitivity Tests
-
Molecular Sequence Data
-
Plasmids / genetics*
-
beta-Lactamases / genetics*
-
beta-Lactamases / isolation & purification
-
beta-Lactamases / metabolism
Substances
-
Bacterial Proteins
-
IMP-8 enzyme
-
beta-lactamase SHV-12
-
beta-Lactamases
-
beta-lactamase TEM-1