Outcome of patients with idiopathic pulmonary fibrosis admitted to the ICU for respiratory failure

Chest. 2001 Jul;120(1):209-12. doi: 10.1378/chest.120.1.209.


Study objectives: To analyze the outcome of acute respiratory failure (ARF) in patients with idiopathic pulmonary fibrosis (IPF), and to evaluate the benefits of invasive and noninvasive mechanical ventilation (MV).

Design: Retrospective study.

Setting: University hospital.

Patients: Fifteen consecutive patients with IPF referred to the ICU for ARF between January 1989 and June 1998.

Measurements and results: Fifteen patients (mean +/- SD age, 64 +/- 10 years) were included. Eight patients had clinical, functional, and radiologic features of IPF, and the remaining seven patients also had biopsy specimen-proven IPF. The mean duration between diagnosis of IPF and admission to the ICU was 26.5 +/- 28 months. At the time of ICU admission, mean arterial blood gas levels were as follows: PaO(2)/fraction of inspired oxygen, 113 +/- 95; pH, 7.32 +/- 0.10; and PaCO(2), 55 +/- 21 mm Hg. All patients received MV; 12 patients required tracheal intubation, either at the time of ICU admission (n = 10) or after failure of noninvasive ventilation (NIV; n = 2); and 3 patients only received NIV. Three of the five patients receiving NIV died of respiratory failure. Eleven patients died in the ICU, either from hypoxemia (n = 8) or from septic shock (n = 3). Four patients were discharged alive from the ICU, and two of them died shortly thereafter.

Conclusion: The outcome of patients with IPF referred to the ICU for ARF was very poor and not improved by MV. Without a clearly identified reversible cause of ARF, these patients should not benefit from admission to the ICU.

MeSH terms

  • Acute Disease
  • Carbon Dioxide / blood
  • Female
  • Hospital Mortality
  • Humans
  • Intensive Care Units
  • Lung / diagnostic imaging
  • Male
  • Middle Aged
  • Oxygen / blood
  • Pulmonary Fibrosis / complications
  • Pulmonary Fibrosis / diagnosis
  • Pulmonary Fibrosis / physiopathology
  • Pulmonary Fibrosis / therapy*
  • Respiration, Artificial
  • Respiratory Function Tests
  • Respiratory Insufficiency / blood
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / mortality
  • Respiratory Insufficiency / therapy*
  • Retrospective Studies
  • Survival Rate
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Carbon Dioxide
  • Oxygen