Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity

Science. 1975 Jul 25;189(4199):301-3. doi: 10.1126/science.1145205.

Abstract

Two rat strains previously shown to differ with respect to behavioral activity, regional brain tyrosine hydroxylase activity, and norepinephrine-elicited accumulation of adenosine 3', 5'-monophosphate exhibited differential behavioral responsiveness during the intraventricular infusion of norepinephrine. The results are interpreted in terms of differential catecholamine receptor sensitivity.

MeSH terms

  • Amphetamine / pharmacology
  • Animals
  • Behavior, Animal / drug effects
  • Brain / drug effects
  • Brain / metabolism*
  • Catheterization
  • Cerebral Ventricles
  • Male
  • Methoxamine / pharmacology
  • Motor Activity
  • Norepinephrine / administration & dosage
  • Norepinephrine / metabolism*
  • Norepinephrine / pharmacology
  • Rats
  • Rats, Inbred BUF / metabolism*
  • Rats, Inbred F344 / metabolism*
  • Rats, Inbred Strains / metabolism*
  • Receptors, Adrenergic
  • Species Specificity

Substances

  • Receptors, Adrenergic
  • Amphetamine
  • Methoxamine
  • Norepinephrine