Nodular localized primary cutaneous amyloidosis: a long-term follow-up study

Br J Dermatol. 2001 Jul;145(1):105-9. doi: 10.1046/j.1365-2133.2001.04291.x.


We present long-term follow-up data on patients with nodular localized primary cutaneous amyloidosis (NLPCA) seen at the St John's Institute of Dermatology between 1968 and 1999. This is the largest clinical follow-up study of this type of amyloid to date. Based on these cases we estimate the rate of progression of NLPCA to systemic amyloidosis to be only 7%, much lower than the 50% rate currently quoted in the literature.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amyloidosis / pathology*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Microscopy, Fluorescence
  • Middle Aged
  • Prognosis
  • Skin Diseases / pathology*