Spinal-cord involvement in diabetic peripheral neuropathy

Lancet. 2001 Jul 7;358(9275):35-6. doi: 10.1016/S0140-6736(00)05268-5.

Abstract

The pathogenesis of diabetic distal symmetrical polyneuropathy (DSP) is poorly understood but there is some evidence that the disease process might extend beyond peripheral nerves. We used magnetic-resonance imaging to measure spinal-cord cross-sectional area in diabetic patients with and without DSP and in healthy controls. There were significant differences in cord area between the groups at C4/5 and T3/4 (p=0.004 and p=0.033, respectively), with a smaller cord area in those with DSP compared with controls (p=0.001 and p=0.016 for C4/5 and T3/4, respectively). These results indicate that DSP is not simply a disease of the peripheral nerve and that there is substantial involvement of the spinal cord.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Diabetic Neuropathies / diagnosis*
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Neurologic Examination
  • Reference Values
  • Spinal Cord / pathology*
  • Spinal Cord Diseases / diagnosis*