Ion homeostasis and apoptosis

Curr Opin Cell Biol. 2001 Aug;13(4):405-11. doi: 10.1016/s0955-0674(00)00228-3.


Alterations in the transmembrane gradients of several physiological ions may influence programmed cell death. In particular, recent data suggest that increases in intracellular calcium may either promote or inhibit apoptosis, depending on the level, timing and location, whereas loss of intracellular potassium promotes apoptosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Calcium Signaling
  • Cell Size
  • Chloride Channels / physiology
  • Homeostasis
  • Ion Transport*
  • Models, Biological
  • Potassium / metabolism


  • Chloride Channels
  • Potassium