Adaptor-related proteins

Curr Opin Cell Biol. 2001 Aug;13(4):444-53. doi: 10.1016/s0955-0674(00)00235-0.


Two new adaptor-related protein complexes, AP-3 and AP-4, have recently been identified, and both have been implicated in protein sorting at the trans-Golgi network (TGN) and/or endosomes. In addition, two families of monomeric proteins with adaptor-related domains, the GGAs and the stoned B family, have also been identified and shown to act at the TGN and plasma membrane, respectively. Together with the two conventional adaptors, AP-1 and AP-2, these proteins may act to direct different types of cargo proteins to different post-Golgi membrane compartments.

Publication types

  • Review

MeSH terms

  • ADP-Ribosylation Factors / chemistry
  • ADP-Ribosylation Factors / genetics
  • ADP-Ribosylation Factors / physiology
  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Vesicular Transport*
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology
  • Drosophila Proteins*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Models, Biological
  • Mutation
  • Nerve Tissue Proteins / physiology
  • Neurons / metabolism
  • Protein Structure, Tertiary
  • Protein Transport
  • trans-Golgi Network / metabolism


  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Vesicular Transport
  • Carrier Proteins
  • Drosophila Proteins
  • GGA adaptor proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • stnB protein, Drosophila
  • ADP-Ribosylation Factors