Dynamin family of mechanoenzymes

Curr Opin Cell Biol. 2001 Aug;13(4):454-60. doi: 10.1016/s0955-0674(00)00236-2.

Abstract

The dynamin family of proteins is continually growing, and in recent years members have been localized to areas of mitochondrial fission, plant phragmoplasts and chloroplasts, and viral ribonucleoprotein complexes. All the dynamin-like proteins examined to-date appear to assemble into oligomers, such as rings or spirals; however, it remains to be determined if a global mechanism of action exists. Even the role of dynamin in vesicle formation remains controversial as to whether it behaves as a molecular switch or as a mechanochemical enzyme.

Publication types

  • Review

MeSH terms

  • Animals
  • Dynamins
  • GTP Phosphohydrolases / chemistry
  • GTP Phosphohydrolases / physiology*
  • Interferon-gamma / physiology
  • Mitochondria / ultrastructure
  • Models, Biological
  • Plant Proteins / physiology
  • Protein Structure, Tertiary
  • Transport Vesicles / enzymology

Substances

  • Plant Proteins
  • Interferon-gamma
  • GTP Phosphohydrolases
  • Dynamins