Implications of Lipid Microdomains for Membrane Curvature, Budding and Fission

Curr Opin Cell Biol. 2001 Aug;13(4):478-84. doi: 10.1016/s0955-0674(00)00239-8.


Recent studies have highlighted the importance of monolayer and bilayer curvature for the budding and fission of biological membranes. Other lines of research, addressing the structure of planar biological membranes, have revealed the existence of cholesterol-based membrane microdomains. Here, we comment on the significance of microdomains for curved membranes, with special emphasis on budding and fission.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / chemistry
  • Cell Membrane / physiology
  • Cytoplasmic Vesicles / metabolism
  • Membrane Lipids / physiology
  • Membrane Microdomains / physiology*
  • Membrane Proteins / physiology


  • Membrane Lipids
  • Membrane Proteins