The role of phosphoinositides in membrane transport

Curr Opin Cell Biol. 2001 Aug;13(4):485-92. doi: 10.1016/s0955-0674(00)00240-4.


Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane trafficking. Recently, phosphoinositides have been found to direct the localization and activity of effector proteins containing consensus sequence motifs such as FYVE, PH and ENTH domains. In addition, recent results show that regulated synthesis and turnover of phosphoinositides by membrane-associated phosphoinoside kinases and phosphatases spatially restrict the location of effectors critical for cellular transport processes, such as clathrin-mediated endocytosis, autophagy, phagocytosis, macropinocytosis and biosynthetic trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autophagy
  • Endocytosis
  • Endosomes / metabolism
  • Models, Biological
  • Phosphatidylinositol 4,5-Diphosphate / physiology
  • Phosphatidylinositol Phosphates / physiology
  • Phosphatidylinositols / physiology*
  • Protein Biosynthesis
  • Protein Transport


  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates
  • Phosphatidylinositols
  • phosphatidylinositol 3-phosphate
  • phosphatidylinositol 4-phosphate