PI(4,5)P(2) Regulation of Surface Membrane Traffic

Curr Opin Cell Biol. 2001 Aug;13(4):493-9. doi: 10.1016/s0955-0674(00)00241-6.


Phosphatidylinositol 4,5-biphosphate (PI[4,5]P(2)) has emerged as an important signaling molecule in the membrane for regulating vesicle exo- and endocytosis and the accompanying actin cytoskeletal rearrangements. Localization studies with GFP-tagged binding domains and antibodies provide new views of the non-uniform, dynamic distribution of PI(4,5)P(2) in membranes and its organization in raft-like domains. The targeting of phosphoinositide kinases by GTPases can coordinate the reactions of membrane fusion and fission with cytoskeletal assembly, providing a basis for membrane movement.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cell Membrane / metabolism
  • Cytoskeleton / metabolism
  • Endocytosis
  • Golgi Apparatus / physiology
  • Membrane Microdomains / chemistry
  • Models, Biological
  • Monomeric GTP-Binding Proteins / physiology
  • Phosphatidylinositol 4,5-Diphosphate / analysis
  • Phosphatidylinositol 4,5-Diphosphate / physiology*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Transport Vesicles / metabolism


  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphotransferases (Alcohol Group Acceptor)
  • Monomeric GTP-Binding Proteins