Microwave-assisted [6+4]-cycloaddition of fulvenes and alpha-pyrones to azulene-indoles: facile syntheses of novel antineoplastic agents

Bioorg Med Chem Lett. 2001 Aug 6;11(15):1981-4. doi: 10.1016/s0960-894x(01)00349-3.

Abstract

A microwave-enhanced [6+4]-cycloaddition reaction between 6-aminofulvene and pyrones followed by CO(2) extrusion provides azulene-indoles which display interesting antineoplastic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Azulenes
  • Cycloheptanes / chemistry
  • Cycloheptanes / pharmacology*
  • Cyclopentanes / chemical synthesis
  • Humans
  • Indoles / chemical synthesis
  • Indoles / pharmacology*
  • Inhibitory Concentration 50
  • Microwaves*
  • Pyrones / chemical synthesis
  • Structure-Activity Relationship
  • Tumor Cells, Cultured / drug effects*

Substances

  • Antineoplastic Agents
  • Azulenes
  • Cycloheptanes
  • Cyclopentanes
  • Indoles
  • Pyrones
  • fulvene
  • azulene