Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis

Ann Rheum Dis. 2001 Aug;60(8):729-35. doi: 10.1136/ard.60.8.729.

Authors

M Cutolo¹, A Sulli, C Pizzorni, B Seriolo, R H Straub

Affiliation

¹ Division of Rheumatology Department of Internal Medicine University of Genova Viale Benedetto XV,6 16136 Genova, Italy. mcutolo@unige.it

No abstract available

Publication types

Review

MeSH terms

Adenosine / metabolism
Animals
Antirheumatic Agents / metabolism
Antirheumatic Agents / pharmacology*
Apoptosis / drug effects
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / metabolism
Arthritis, Rheumatoid / pathology
Cell Cycle / drug effects
Cyclic AMP / metabolism
Cyclooxygenase Inhibitors / pharmacology
Cytokines / drug effects
Cytokines / metabolism
Humans
Metalloendopeptidases / drug effects
Metalloendopeptidases / metabolism
Methotrexate / metabolism
Methotrexate / pharmacology*
Rats
fas Receptor / drug effects
fas Receptor / metabolism

Substances

Antirheumatic Agents
Cyclooxygenase Inhibitors
Cytokines
fas Receptor
Cyclic AMP
Metalloendopeptidases
Adenosine
Methotrexate