Magnesium causes nitric oxide independent coronary artery vasodilation in humans

Heart. 2001 Aug;86(2):212-6. doi: 10.1136/heart.86.2.212.

Abstract

Objective: To determine how magnesium affects human coronary arteries and whether endothelium derived nitric oxide (EDNO) is involved in the coronary arterial response to magnesium.

Design: Quantitative coronary angiography and Doppler flow velocity measurements were used to determine the effects of the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA) on magnesium induced dilation of the epicardial and resistance coronary arteries.

Setting: Hiroshima University Hospital a tertiary cardiology centre.

Patients: 17 patients with angiographically normal coronary arteries.

Interventions: Magnesium sulfate (MgSO(4)) (0.02 mmol/min and 0.2 mmol/min) was infused for two minutes into the left coronary ostium before and after intracoronary infusion of L-NMMA.

Main outcome measures: Diameter of the proximal and distal segments of the epicardial coronary arteries and coronary blood flow.

Results: At a dose of 0.02 mmol/min, MgSO(4) did not affect the coronary arteries. At a dose of 0.2 mmol/min, MgSO(4) caused coronary artery dilation (mean (SEM) proximal diameter 3.00 (0.09) to 3.11 (0.09) mm; distal 1.64 (0.06) to 1.77 (0.07) mm) and increased coronary blood flow (79.3 (7.5) to 101.4 (9.9) ml/min, p < 0.001 v baseline for all). MgSO(4) increased the changes in these parameters after the infusion of L-NMMA (p < 0.001 v baseline).

Conclusions: Magnesium dilates both the epicardial and resistance coronary arteries in humans. Furthermore, the coronary arterial response to magnesium is dose dependent and independent of EDNO.

MeSH terms

  • Adult
  • Aged
  • Blood Flow Velocity
  • Coronary Circulation / drug effects
  • Coronary Vessels / drug effects*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Female
  • Humans
  • Magnesium Sulfate / administration & dosage
  • Magnesium Sulfate / pharmacology*
  • Male
  • Middle Aged
  • Nitric Oxide / physiology
  • Vasodilation*
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / pharmacology*
  • omega-N-Methylarginine / pharmacology

Substances

  • Enzyme Inhibitors
  • Vasodilator Agents
  • omega-N-Methylarginine
  • Nitric Oxide
  • Magnesium Sulfate