Spatio-temporal source imaging reveals subcomponents of the human auditory mismatch negativity in the cingulum and right inferior temporal gyrus

Neurosci Lett. 2001 Aug 3;308(2):107-10. doi: 10.1016/s0304-3940(01)01988-7.


We investigated the generators of the mismatch negativity by means of spatio-temporal source imaging on the basis of 64-channel electroencephalography data in order to study the time course and localization of proposed frontal sources. Results indicate that there are additional generators located both within the anterior cingulate gyrus and in the right inferior temporal gyrus, clearly separated from the supratemporal generators in space and time course. The cingulate generator is activated later than the temporal ones, which supports the hypothesis of a frontally located mechanism of involuntary switching of attention triggered by the temporal change detection system. Evidence for an additional right inferior temporal generator supports the hypothesis of right hemispheric dominance in early sound discrimination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Algorithms
  • Attention / physiology*
  • Audiometry, Evoked Response
  • Brain Mapping*
  • Electroencephalography / methods*
  • Evoked Potentials, Auditory / physiology
  • Female
  • Functional Laterality / physiology*
  • Gyrus Cinguli / anatomy & histology
  • Gyrus Cinguli / physiology*
  • Humans
  • Magnetoencephalography / methods
  • Male
  • Reaction Time / physiology
  • Sound Localization / physiology*
  • Temporal Lobe / anatomy & histology
  • Temporal Lobe / physiology*