Leiomyosarcoma of the female breast

Pathol Oncol Res. 2001;7(2):151-3. doi: 10.1007/BF03032583.


Leiomyosarcomas of the breast are rare tumors. Less than 15 such cases have been reported in the literature so far. In this paper authors describe a case of leiomyosarcoma of a female breast presenting as a firm lobulated mass, mimicking a phylloid tumor radiographically. By fine needle aspiration biopsy, on the smears discohesive malignant looking cells were conclusive to a poorly differentiated invasive ductal carcinoma of the breast. The mastectomy specimen contained a lobulated mass, microscopically showing a partly epithelioid spindle cell tumor, immunoreactive for vimentin, desmin, smooth muscle actin antibodies, and negative for epithelial markers, hormone and growth factor receptors. Axillary lymph nodes were free of tumor. A primary leiomyosarcoma of the breast was diagnosed.

Publication types

  • Case Reports

MeSH terms

  • Actins / analysis
  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy, Needle
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / pathology*
  • Carcinoma, Ductal, Breast / diagnosis
  • Desmin / analysis
  • Diagnosis, Differential
  • Female
  • Humans
  • Leiomyosarcoma / chemistry
  • Leiomyosarcoma / diagnosis
  • Leiomyosarcoma / pathology*
  • Neoplasm Proteins / analysis
  • Phyllodes Tumor / diagnosis
  • Vimentin / analysis


  • Actins
  • Biomarkers, Tumor
  • Desmin
  • Neoplasm Proteins
  • Vimentin