The Reaction Mechanism of the Enzyme-Catalyzed Central Cleavage of beta-Carotene to Retinal This Research Was Supported by F. Hoffmann-La Roche AG and the Swiss National Science Foundation. We Are Grateful to F. Hoffmann-La Roche AG for a Generous Gift of Carotenoids and Dr. Claus Bornemann for Preliminary Experiments

Angew Chem Int Ed Engl. 2001 Jul 16;40(14):2613-2617.