Cellular mechanisms of baroreceptor integration at the nucleus tractus solitarius

Ann N Y Acad Sci. 2001 Jun;940:132-41. doi: 10.1111/j.1749-6632.2001.tb03672.x.

Abstract

The autonomic nervous system makes important contributions to the homeostatic regulation of the heart and blood vessels through arterial baroreflexes, and yet our understanding of the central nervous system mechanisms is limited. The sensory synapse of baroreceptors in the nucleus tractus solitarius (NTS) is unique because its participation is obligatory in the baroreflex. Here we describe experiments targeting this synapse to provide greater understanding of the cellular mechanisms at the earliest stages of the baroreflex. Our approach utilizes electrophysiology, pharmacology, and anatomical tracers to identify and evaluate key elements of the sensory information processing in NTS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Baroreflex / physiology
  • Glutamic Acid / physiology
  • Neural Pathways / physiology
  • Neurons, Afferent / physiology
  • Pressoreceptors / physiology*
  • Solitary Nucleus / physiology*
  • Synapses / physiology
  • Synaptic Transmission / physiology

Substances

  • Glutamic Acid