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. 2001 Aug;57(2):151-5.
doi: 10.1054/mehy.2001.1307.

The Possible Role of Vitamin K Deficiency in the Pathogenesis of Alzheimer's Disease and in Augmenting Brain Damage Associated With Cardiovascular Disease

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The Possible Role of Vitamin K Deficiency in the Pathogenesis of Alzheimer's Disease and in Augmenting Brain Damage Associated With Cardiovascular Disease

A C Allison. Med Hypotheses. .

Abstract

The incidence of Alzheimer's disease (AD) increases with age and in carriers of the apolipoprotein E4 genotype. A relative deficiency of vitamin K, affecting the extrahepatic functions of the vitamin, is common in ageing men and women. The concentration of vitamin K is lower in the circulating blood of APOE4 carriers than in that of persons with other APOE genotypes. Evidence is accumulating that vitamin K has important functions in the brain, including the regulation of sulfotransferase activity and the activity of a growth factor/tyrosine kinase receptor (Gas 6/Axl). The hypothesis is now proposed that vitamin K deficiency contributes to the pathogenesis of AD and that vitamin K supplementation may have a beneficial effect in preventing or treating the disease. Vitamin K may also reduce neuronal damage associated with cardiovascular disease.

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