Tularemia Epidemic in Northwestern Spain: Clinical Description and Therapeutic Response

Clin Infect Dis. 2001 Aug 15;33(4):573-6. doi: 10.1086/322601. Epub 2001 Jul 6.

Abstract

This study describes the clinical characteristics of tularemia in Spain's first epidemic outbreak and the therapeutic response and compares the efficacy of 3 antibiotics (streptomycin, ciprofloxacin, and doxycycline). For 142 cases of tularemia, the therapeutic failure rate was 22.5%; ciprofloxacin was the antibiotic with the lowest percentage of therapeutic failures and with the fewest side effects.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Antibodies, Bacterial / blood
  • Disease Outbreaks*
  • Female
  • Francisella tularensis / immunology
  • Francisella tularensis / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Spain / epidemiology
  • Treatment Outcome
  • Tularemia / drug therapy
  • Tularemia / epidemiology*
  • Tularemia / microbiology
  • Tularemia / physiopathology

Substances

  • Anti-Bacterial Agents
  • Antibodies, Bacterial