Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase)

J Med Chem. 2001 Feb 1;44(3):298-301. doi: 10.1021/jm000406m.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / enzymology
  • Carboxypeptidases / antagonists & inhibitors*
  • Cells, Cultured
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Excitatory Amino Acid Agonists
  • Glutamate Carboxypeptidase II
  • N-Methylaspartate
  • Neuroglia / cytology
  • Neuroglia / drug effects
  • Neuroprotective Agents / chemical synthesis*
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology
  • Rats
  • Structure-Activity Relationship
  • Urea / analogs & derivatives*
  • Urea / chemical synthesis*
  • Urea / chemistry
  • Urea / pharmacology

Substances

  • Enzyme Inhibitors
  • Excitatory Amino Acid Agonists
  • Neuroprotective Agents
  • N-Methylaspartate
  • Urea
  • Carboxypeptidases
  • Glutamate Carboxypeptidase II