Abstract
[reaction: see text] An annulative approach toward the total synthesis of the sesterterpenoid variecolin (1) is presented. Synthesis of the key hemiketal, containing the core ABC ring skeleton, has been achieved on a model system by an expeditious route utilizing samarium(II) iodide. Furthermore, enantioselective syntheses of component fragments for the total synthesis have been developed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Angiotensin Receptor Antagonists
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Immunosuppressive Agents / chemical synthesis
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Receptor, Angiotensin, Type 1
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Receptor, Angiotensin, Type 2
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Sesterterpenes
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Stereoisomerism
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Terpenes / chemical synthesis*
Substances
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Angiotensin Receptor Antagonists
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Immunosuppressive Agents
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Receptor, Angiotensin, Type 1
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Receptor, Angiotensin, Type 2
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Sesterterpenes
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Terpenes
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variecolin